ABSTRACT
To study the protective role of taurine in tamoxifen-induced hepatic steatosis in albino rats. Prospectve experimental study. Department of Anatomy, Khyber Medical College, Peshawar, from July 2011 to November 2011. Four groups of female albino rats, each containing 8 animals, were treated for 21 days as follows: Group A served control, Group B treated with tamoxifen, Group C treated with tamoxifen plus taurine, Group D treated with taurine alone. The animals were weighed at the start and end of treatment and then sacrificed under ether anaesthesia. The livers were fixed in 10% formalin and embedded in paraffin. H and E stained 4 micro thick sections were examined microscopically. There was significant decrease in the body weights of groups B and C as compared groups A and D. Significant increase in the body weights of group C rats in comparison with group B was noted. Histologically the livers of group B animals showed generalized microvesicular and macrovesicular steatosis, with no evidence of hepatocyte necrosis. In group C the fatty change was much less pronounced as compared to group B. The study data suggest that taurine supplementation can reverse / attenuate the hepatic steatosis caused by tamoxifen treatment for 21 days, in albino rats
ABSTRACT
The present study was planned to observe the activity of cefuroxime, a second generation cephalosporin after combining it with a beta-lactamase inhibitor calvulanic acid. The study was conducted to evaluate the restoration or increase in sensitivity of beta-lactamase producing isolates of Staphylococcus aureus. Staphylococcus aureus were identified by standard procedures. For beta-lactamase detection chromogenic Nitrocefin impregnated sticks were used. The sensitivity of the bacteria to the antibiotic disks was measured by disk diffusion method using standard zone diameter criteria given by National Committee of Clinical Laboratory Standards. The disks of cefuroxime with clavulanic acid had developed larger zones of inhibition. The activity of cefuroxime against Staphylococcus aureus was significantly increased by clavulanic acid. Clavulanic acid if used in combination with cefuroxime, can improve the antimicrobial activity of cefuroxime against beta-lactamase producing Staphylococcus aureus